Scientist vacancy at USP-Chemistry Candidates Apply Online

MSc Chemistry job as Scientist at USP, Analytical Research & Development Laboratory. Interested chemistry candidates can apply now online.

Job title – Scientist I, ARD – NMR

Job location – Hyderabad, India

Job Overview- 

This is a non-supervisory position in USP-India’s Analytical Research & Development Laboratory. In this role, the Scientist – I is responsible for providing NMR support for the characterization or identification of samples received from various laboratories of USP India such as ARD, Synthetic chemistry, RSL, Verification, CDL and Biologics. The Scientist I performs a variety of non-routine and routine NMR tests, including evaluation of reference standards, evaluation of packaging materials and stability studies, and general research in NMR Lab.

Job description for MSc Chemistry job as Scientist –

• Responsible for operating, and maintenance of 500 MHz NMR instrument, recording and interpretation of NMR spectra for samples submitted by the Synthetic Organic Chemistry Lab, Reference Standards Lab, Biologics & Biotechnology Lab, and other sources as per ISO 17025.
• Support to synthetic R&D projects from start to completion as per ISO 9001
• Assist and maintain the safety aspects in the laboratory
• Performs other related duties as per requirement
• Prepare for ISO-9001 & ISO-17025 audits and related activities
• Ensure that the calibrations of the equipment are performed as per the schedule.
• Responsible for preparing, executing and completing IQ/OQ/PQ of new instruments.
• Ensure the lab requirements like glassware, chemicals and columns for NMR lab.
• Ensure to follow USP Policies and Procedures.

Candidate requirements-

The successful candidate will have a demonstrated understanding of our mission, commitment to excellence through inclusive and equitable behaviors and practices, ability to quickly build credibility with stakeholders, along with the following competencies and experience:

• MSc. in Analytical Chemistry / Organic Chemistry, from a well-recognized University in India or abroad and required not less than 2 years’ experience in handling the NMR spectrometer.
• Extensive NMR knowledge both in running the equipment and interpretation of results and characterization of the compound by spectral techniques (NMR, MASS and IR). Must possess a strong work ethic and a solid record of problem solving and technical results.
• Experience in small molecule structure elucidation using NMR.
• Must be familiar with electronic notebook documentation of experimental procedures.
• Ability to embrace and lead change. Extremely adaptable. Excellent communication skills, both written and verbal.
• Good interpersonal skills and proven ability to function in a team-oriented environment are necessary. Understanding of GMP / ISO-IEC 17025 Guidelines is a requirement

Additional Desired Preferences-

• Experience on biological molecules such as peptides, proteins and vaccines would be an added advantage.
• Knowledge of solid state NMR and multinuclear NMR operations is an advantage.
• Proven track record of consistently delivering projects on time and with high quality
• Prior experience in a high volume pharmaceutical ARD laboratory or contract pharmaceutical analytical laboratory testing organization is a plus.
• Takes personal responsibility for delivery of projects to customers.
• Expertise with Bruker NMR software- automation software & hardware including cryo-probes.
• Comprehensive understanding of the science involved in the development of synthetic organic molecules and analytical chemistry. ACD & Chemdraw software’s handling is an added advantage. Proven self-effectiveness skills are must.

Apply online

Hi there, You can go through the following expected questions that are provided below after applying for the MSc Chemistry job as Scientist. Prepare well and All the very best for your interview.

Question: Can you describe your experience in operating and maintaining NMR instruments, specifically 500 MHz NMR instruments?
Answer: Yes, I have extensive experience in operating and maintaining 500 MHz NMR instruments. I have been responsible for the day-to-day operation of the instrument, including calibration, troubleshooting, and routine maintenance. I am well-versed in acquiring high-quality NMR spectra and ensuring the instrument’s optimal performance. Additionally, I have experience with the specific requirements and protocols related to ISO 17025 standards for NMR testing.

Question: How would you approach small molecule structure elucidation using NMR techniques?
Answer: Small molecule structure elucidation using NMR techniques requires a systematic approach. Firstly, I would carefully prepare and acquire high-quality NMR spectra of the sample. Then, I would analyze the chemical shifts, multiplicity, and coupling constants of the peaks to determine the connectivity of the atoms in the molecule. By comparing the obtained data with known spectral patterns and databases, I can propose possible structures. Further, I would use 2D NMR techniques such as COSY, HSQC, and HMBC to confirm and refine the structure. Overall, a combination of spectral interpretation, database comparison, and 2D NMR techniques would be employed for small molecule structure elucidation.

Question: Can you describe your experience with ISO-9001 and ISO-17025 audits and related activities?
Answer: I have actively participated in ISO-9001 and ISO-17025 audits and related activities in my previous roles. I am familiar with the documentation requirements, quality management systems, and audit procedures associated with these standards. I have collaborated with quality assurance teams to prepare for audits, ensure compliance with the standards, and address any non-conformities. I am well-versed in implementing corrective and preventive actions to maintain and improve quality systems. Additionally, I have experience in preparing and updating standard operating procedures (SOPs) and ensuring adherence to ISO guidelines throughout laboratory operations.

Question: Have you worked with biological molecules such as peptides, proteins, or vaccines in an NMR laboratory?
Answer: While my primary experience lies in small molecule NMR analysis, I have a strong theoretical understanding of the NMR techniques applicable to biological molecules. I have studied and worked with spectral techniques such as NMR, mass spectrometry, and IR spectroscopy, which are commonly used for the characterization of peptides, proteins, and vaccines. While I may not have direct hands-on experience with these specific molecules in an NMR laboratory, I am confident in my ability to apply my knowledge and adapt my skills to analyze and interpret NMR data for biological samples.

Question: Can you discuss your familiarity with Bruker NMR software and automation hardware, including cryo-probes?
Answer: I am highly familiar with Bruker NMR software and automation hardware, including cryo-probes. I have utilized Bruker software extensively for data acquisition, processing, and spectral analysis. I am proficient in setting up experiments, optimizing parameters, and performing advanced spectral processing using the software. Regarding automation hardware, I have experience in operating and troubleshooting automated NMR systems integrated with Bruker software. Cryo-probes, known for their enhanced sensitivity, have been part of my NMR work, and I am proficient in their handling and maintenance. My expertise with Bruker software and automation hardware enables efficient and accurate data acquisition and analysis in an NMR laboratory setting.